diff --git a/Koha/Acquisition/Basket.pm b/Koha/Acquisition/Basket.pm
index ebdbce6190..9ea54b48e4 100644
--- a/Koha/Acquisition/Basket.pm
+++ b/Koha/Acquisition/Basket.pm
@@ -135,6 +135,30 @@ sub edi_order {
     return $order_rs->single;
 }
 
+=head3 edi_quote
+
+  my $edi_order = $basket->edi_quote;
+
+Returns the EDI quote object if one was used to generate this basket.
+
+NOTE: This currently returns a bare DBIx::Class result or undefined. This is consistent with the rest of EDI;
+However it would be beneficial to convert these to full fledge Koha::Objects in the future.
+
+=cut
+
+sub edi_quote {
+    my ($self) = @_;
+
+    my $order_rs = $self->_result->edifact_messages(
+        {
+            message_type => 'QUOTE',
+            deleted      => 0
+        },
+        { order_by => { '-desc' => 'transfer_date' }, rows => 1 }
+    );
+    return $order_rs->single;
+}
+
 =head3 effective_create_items
 
 Returns C<create_items> for this basket, falling back to C<AcqCreateItem> if unset.
diff --git a/acqui/basketheader.pl b/acqui/basketheader.pl
index 26848d36c5..5a1162d5b4 100755
--- a/acqui/basketheader.pl
+++ b/acqui/basketheader.pl
@@ -56,6 +56,7 @@ use C4::Contract    qw( GetContracts GetContract );
 use Koha::Acquisition::Booksellers;
 use Koha::Acquisition::Baskets;
 use Koha::AdditionalFields;
+use Koha::Database;
 
 my $input = CGI->new;
 my ( $template, $loggedinuser, $cookie ) = get_template_and_user(
@@ -122,6 +123,24 @@ if ( $op eq 'add_form' ) {
         );
     }
 
+    # Check if basket name should be read-only (EDI-generated with PO number setting)
+    my $basket_name_readonly = 0;
+    if ( $basketno && $basket ) {
+        my $basket_obj = Koha::Acquisition::Baskets->find($basketno);
+        if ($basket_obj) {
+            my $edi_quote = $basket_obj->edi_quote;
+            if ($edi_quote) {
+
+                # This basket was created from an EDI quote
+                # Check if the vendor EDI account is configured to use purchase order numbers
+                my $vendor_edi_account = $edi_quote->edi_acct;
+                if ( $vendor_edi_account && $vendor_edi_account->po_is_basketname ) {
+                    $basket_name_readonly = 1;
+                }
+            }
+        }
+    }
+
     $template->param(
         add_form             => 1,
         basketname           => $basket->{'basketname'},
@@ -132,6 +151,7 @@ if ( $op eq 'add_form' ) {
         basketno             => $basketno,
         is_standing          => $basket->{is_standing},
         create_items         => $basket->{create_items},
+        basket_name_readonly => $basket_name_readonly,
     );
 
     my $billingplace  = $basket->{'billingplace'}  || C4::Context->userenv->{"branch"};
@@ -145,9 +165,34 @@ if ( $op eq 'add_form' ) {
 
     #we are confirming the changes, save the basket
     if ($is_an_edit) {
+
+        # Check if basket name should be protected from changes
+        my $basket_name    = scalar $input->param('basketname');
+        my $current_basket = GetBasket($basketno);
+
+        # If this basket was created from EDI with PO number setting, prevent name changes
+        my $basket_obj = Koha::Acquisition::Baskets->find($basketno);
+        if ($basket_obj) {
+            my $edi_order = $basket_obj->edi_order;
+            if ($edi_order) {
+
+                # This basket was created from an EDI order/quote
+                # Check if the vendor EDI account is configured to use purchase order numbers
+                my $schema             = Koha::Database->new()->schema();
+                my $vendor_edi_account = $schema->resultset('VendorEdiAccount')
+                    ->search( { vendor_id => scalar $input->param('basketbooksellerid') } )->first;
+
+                if ( $vendor_edi_account && $vendor_edi_account->po_is_basketname ) {
+
+                    # Preserve the original basket name
+                    $basket_name = $current_basket->{'basketname'};
+                }
+            }
+        }
+
         ModBasketHeader(
             $basketno,
-            scalar $input->param('basketname'),
+            $basket_name,
             scalar $input->param('basketnote'),
             scalar $input->param('basketbooksellernote'),
             scalar $input->param('basketcontractnumber') || undef,
diff --git a/koha-tmpl/intranet-tmpl/prog/en/modules/acqui/basketheader.tt b/koha-tmpl/intranet-tmpl/prog/en/modules/acqui/basketheader.tt
index 1468aab6da..e50b1e8947 100644
--- a/koha-tmpl/intranet-tmpl/prog/en/modules/acqui/basketheader.tt
+++ b/koha-tmpl/intranet-tmpl/prog/en/modules/acqui/basketheader.tt
@@ -68,8 +68,14 @@
                     [% END %]
                     <li>
                         <label for="basketname" class="required">Basket name: </label>
-                        <input type="text" name="basketname" id="basketname" size="40" maxlength="80" value="[% basketname | html %]" required="required" class="focus required" />
-                        <span class="required">Required</span>
+                        [% IF basket_name_readonly %]
+                            <input type="text" name="basketname" id="basketname" size="40" maxlength="80" value="[% basketname | html %]" required="required" class="focus required" readonly="readonly" />
+                            <span class="required">Required</span>
+                            <div class="hint">This basket name is derived from the purchase order number and cannot be changed.</div>
+                        [% ELSE %]
+                            <input type="text" name="basketname" id="basketname" size="40" maxlength="80" value="[% basketname | html %]" required="required" class="focus required" />
+                            <span class="required">Required</span>
+                        [% END %]
                     </li>
                     <li>
                         <label for="billingplace">Billing place: </label>